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Taking LONSURF

What is LONSURF?

For patients with colon or rectal cancer:

LONSURF® (trifluridine and tipiracil) tablets are a prescription medicine for colon or rectal cancer.

For patients with stomach cancer:

LONSURF tablets are a prescription medicine for stomach cancer. Stomach cancer is sometimes called gastric cancer.

  • Your healthcare provider may have told you that you have gastroesophageal junction cancer, which is a type of cancer located in the lower part of the esophagus that connects to the stomach.

LONSURF is an oral tablet, which means it is taken by mouth. It is a prescription chemotherapy tablet that is made up of 2 parts. LONSURF offers you a chance to continue cancer treatment. It may help you live longer and slow or stop the growth of cancer in your body for a period of time.

Living with colon, rectal or stomach cancer can be difficult, but you are not alone. You are facing it with your family, friends, and loved ones. LONSURF may give you the chance to continue the journey longer alongside them.

Who should take LONSURF?

LONSURF tablets are for those:

  • Living with colon, rectal or stomach cancer that has spread to other parts of the body
  • Who have been previously treated with or cannot receive certain chemotherapy medicines
  • Who now may need another option

If you aren’t sure what treatments you’ve had in the past, ask your healthcare provider.

Do not use LONSURF if you are allergic to any of the ingredients in LONSURF.
Talk to your healthcare provider if you are not sure whether you are allergic to any of the ingredients in LONSURF.

What is the effectiveness of LONSURF?

With proven results to help patients live longer, LONSURF may allow you to continue your journey with cancer.

LONSURF has been proven to:

  • Allow some patients to live longer
  • Slow or stop the growth of cancer for a period of time

Colon or Rectal Cancer

LONSURF was studied in a clinical trial of 800 patients with colon or rectal cancer that had spread to other parts of the body and had been previously treated with certain chemotherapy medicines.

  • Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
  • Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo

Stomach Cancer

LONSURF was studied in a clinical trial of 507 patients with stomach cancer that had spread to other parts of the body and had been previously treated with certain chemotherapy medicines.

  • Half of the patients treated with LONSURF were still alive at 5.7 months and half of the patients who received placebo were still alive at 3.6 months
  • Worsening of the disease or death occurred in 85% of patients treated with LONSURF and 92% of patients who received placebo
Questions to ask your doctor

How it works

LONSURF is a prescription medicine used to treat people with colon, rectal, or stomach cancer that has spread to other parts of the body and who have been previously treated with or cannot receive certain chemotherapy medicines. LONSURF consists of two medicines in one:

  • One part (tipiracil) helps the other part (trifluridine) stay active and work properly and stops cells from making copies of themselves. This may help stop tumors from growing

SEE ALL INDICATIONS

INDICATIONS

LONSURF is a prescription medicine used to treat adults with

  • colorectal cancer that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medicines.
  • a kind of stomach cancer called gastric cancer including cancer of the gastroesophageal junction that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medications.

It is not known if LONSURF is safe and effective in children

Indications and Important Safety Information +

INDICATIONS

LONSURF is a prescription medicine used to treat adults with

  • colorectal cancer that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medicines.
  • a kind of stomach cancer called gastric cancer including cancer of the gastroesophageal junction that has spread to other parts of the body and who have been previously treated or cannot receive certain chemotherapy medications.

It is not known if LONSURF is safe and effective in children

IMPORTANT SAFETY INFORMATION

LONSURF may cause serious side effects, including:

  • Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life-threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts

Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.

Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:

  • Have kidney or liver problems
  • Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby.
    • Females who can become pregnant: Your healthcare provider will verify your pregnancy status before you start treatment with LONSURF. You should use effective birth control during and 6 months after the last dose of treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
    • Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
  • Are breast-feeding or plan to breast-feed. It is not known if LONSURF passes into your breast milk. Do not breast-feed during treatment with LONSURF and for 1 day after your last dose of LONSURF

Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take.

The most common side effects with LONSURF include tiredness (fatigue, weakness), nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.

Please see full Prescribing Information.