Considering
LONSURF
WHAT IS
LONSURF?
Learn about treatment with LONSURF
Understand treatment with LONSURF® (trifluridine and tipiracil) tablets–who it is for, how to take it, and how it works in the body.
For patients with colon or rectal cancer:
LONSURF® (trifluridine and tipiracil) tablets are a prescription medicine for colon or rectal cancer.
For patients with stomach cancer:
LONSURF tablets are a prescription medicine for stomach cancer. Stomach cancer is sometimes called gastric cancer.
Your healthcare provider may have told you that you have gastroesophageal junction cancer, which is a type of cancer located in the lower part of the esophagus that connects to the stomach.
LONSURF is an oral tablet, which means it is taken by mouth. It is a prescription chemotherapy tablet that is made up of 2 parts. LONSURF offers you a chance to continue cancer treatment. It may help you live longer and slow or stop the growth of cancer in your body for a period of time.
Living with colon, rectal or stomach cancer can be difficult, but you are not alone. You are facing it with your family, friends, and loved ones. LONSURF may give you the chance to continue the journey longer alongside them.
WHO SHOULD
TAKE LONSURF?
LONSURF tablets are for those:
- Living with colon, rectal or stomach cancer that has spread to other parts of the body
- Who have been previously treated with or cannot receive certain chemotherapy medicines
- Who now may need another option
If you aren’t sure what treatments you’ve had in the past, ask your healthcare provider.
Do not use LONSURF if you are allergic to any of the ingredients in LONSURF.
Talk to your healthcare provider if you are not sure whether you are allergic to any of the ingredients in LONSURF.
WHAT IS THE
EFFICACY
AND SUCCESS RATE
OF LONSURF?
With proven results shown to help patients live longer, LONSURF may allow you to continue your journey with cancer.
LONSURF has been proven to:
- Allow some patients to live longer
- Slow or stop the growth of cancer for a period of time
Colon or Rectal Cancer
LONSURF was studied in a clinical trial of 800 patients with colon or rectal cancer that had spread to other parts of the body and had been previously treated with certain chemotherapy medicines.
- Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
- Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo
Stomach Cancer
LONSURF was studied in a clinical trial of 507 patients with stomach cancer that had spread to other parts of the body and had been previously treated with certain chemotherapy medicines
- Half of the patients treated with LONSURF were still alive at 5.7 months and half of the patients who received placebo were still alive at 3.6 months
- Worsening of the disease or death occurred in 85% of patients treated with LONSURF and 92% of patients who received placebo
HOW IT WORKS
LONSURF is a prescription medicine used to treat people with colon, rectal, or stomach cancer that has spread to other parts of the body and who have been previously treated with or cannot receive certain chemotherapy medicines. LONSURF consists of two medicines in one:
- One part (tipiracil) helps the other part (trifluridine) stay active and work properly and stops cells from making copies of themselves. This may help stop tumors from growing
SEE ALL INDICATIONS
INDICATIONS
LONSURF is a prescription medicine used:
- alone or in combination with the medicine bevacizumab to treat adults with colorectal cancer:
- that has spread to other parts of the body, and
- who have been previously treated with certain chemotherapy medicines
- alone to treat adults with a kind of stomach cancer called gastric cancer including adenocarcinoma of the gastroesophageal junction:
- that has spread to other parts of the body, and
- who have been previously treated with at least 2 types of treatment which included certain medicines
It is not known if LONSURF is safe and effective in children.
INDICATIONS
LONSURF is a prescription medicine used:
- alone or in combination with the medicine bevacizumab to treat adults with colorectal cancer:
- that has spread to other parts of the body, and
- who have been previously treated with certain chemotherapy medicines
- alone to treat adults with a kind of stomach cancer called gastric cancer including adenocarcinoma of the gastroesophageal junction:
- that has spread to other parts of the body, and
- who have been previously treated with at least 2 types of treatment which included certain medicines
It is not known if LONSURF is safe and effective in children.
IMPORTANT SAFETY INFORMATION
LONSURF may cause serious side effects, including:
- Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life-threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts
Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.
Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:
- Have kidney or liver problems
- Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby
- Females who can become pregnant: Your healthcare provider will do a pregnancy test before you start treatment with LONSURF. You should use effective birth control during and 6 months after the last dose of treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
- Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
- Are breastfeeding or plan to breastfeed. It is not known if LONSURF passes into your breast milk. Do not breastfeed during treatment with LONSURF and for 1 day after your last dose of LONSURF
Tell your healthcare provider about all the prescription and over-the-counter medicines, vitamins, and herbal supplements you take.
The most common side effects of LONSURF when used alone include low blood counts, tiredness and weakness, nausea, decreased appetite, diarrhea, vomiting, stomach-area (abdominal) pain, and fever.
The most common side effects of LONSURF when used in combination with bevacizumab include low blood counts, tiredness and weakness, nausea, certain abnormal liver function blood tests, decreased salt (sodium) in your blood, diarrhea, stomach-area (abdominal) pain, and decreased appetite.
Tell your healthcare provider if you have nausea, vomiting, or diarrhea that is severe or that does not go away.
These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.