INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
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Doctor Discussion Guide

To receive a list of helpful questions to ask, please choose one of the following options. Remember to print or download your Guide and share it at your next appointment.

I am a patient

Talking to your healthcare provider about LONSURF® (trifluridine and tipiracil)

If you have colon or rectal cancer that has spread to other parts of your body and have previously been treated with or cannot receive certain chemotherapy medicines, LONSURF might be another treatment option that can allow you to pursue more moments.

LONSURF was studied in a clinical trial of 800 patients.

  • Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
  • Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo

Your doctor or nurse can help you find out whether LONSURF is right for you. Be sure to bring this guide to your next appointment, and use the following questions to help start the conversation.

Look over the following options and check the treatment(s) you have already received:

  • Fluoropyrimidine ‑ such as 5‑fluorouracil, also known as 5-FU, and Xeloda® (capecitabine)
  • Oxaliplatin‑based treatment ‑ such as FOLFOX (5‑FU, leucovorin, and oxaliplatin) and Eloxatin® (oxaliplatin)
  • Irinotecan‑based treatment ‑ such as FOLFIRI (5-FU, leucovorin, and irinotecan) and Camptosar® (irinotecan)
  • Anti‑VEGF biological therapy ‑ such as Avastin® (bevacizumab) and Zaltrap® (ziv‑aflibercept)
  • Anti‑EGFR therapy ‑ such as Erbitux® (cetuximab) and Vectibix® (panitumumab)
  • I'm not sure which treatments I've had

Registered trademarks are the property of their respective owners.

In a clinical trial, LONSURF was shown to be effective in patients who had already taken some or all of the treatments mentioned above.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. However, for most patients in the trial, these side effects did not cause them to stop taking LONSURF (3.6% of patients taking LONSURF stopped vs 1.5% of patients taking placebo).

Additional questions to ask:

  1. Based on the treatments I have previously taken, could LONSURF be right for me?
  2. How can LONSURF help?
  3. How does LONSURF work?
  4. How and where do I take LONSURF?
  5. What is the dosage schedule?
  6. What would my dose be?
  7. How often will I need to come in to the office with this treatment?
  8. What happens if I miss a dose?
  9. When should I call you if I'm having signs and symptoms of side effects?
  10. How can I help manage any side effects I may have?
  11. How will my treatment affect my daily activities or my ability to work?
  12. Does Taiho Oncology offer any financial assistance programs?
Download

I am a caregiver

Talking to your loved one's healthcare provider about LONSURF® (trifluridine and tipiracil)

For those with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines, LONSURF might be another treatment option that can allow them to pursue more moments.

LONSURF was studied in a clinical trial of 800 patients.

  • Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
  • Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo

Your loved one's doctor or nurse can help you find out whether LONSURF is right for your loved one. Be sure to bring this guide to your loved one's next appointment, and use the following questions to help start the conversation.

Look over the following options and check the treatment(s) your loved one has already received:

  • Fluoropyrimidine ‑ such as 5‑fluorouracil, also known as 5-FU, and Xeloda® (capecitabine)
  • Oxaliplatin‑based treatment ‑ such as FOLFOX (5-FU, leucovorin, and oxaliplatin) and Eloxatin® (oxaliplatin)
  • Irinotecan‑based treatment ‑ such as FOLFIRI (5-FU, leucovorin, and irinotecan) and Camptosar® (irinotecan)
  • Anti‑VEGF biological therapy ‑ such as Avastin® (bevacizumab) and Zaltrap® (ziv‑aflibercept)
  • Anti‑EGFR therapy ‑ such as Erbitux® (cetuximab) and Vectibix® (panitumumab)

Registered trademarks are the property of their respective owners.

In a clinical trial, LONSURF was shown to be effective in patients who had already taken some or all of the treatments mentioned above.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. However, for most patients in the trial, these side effects did not cause them to stop taking LONSURF (3.6% of patients taking LONSURF stopped vs 1.5% of patients taking placebo).

Here are some questions to ask your loved one's healthcare provider at their next appointment:

  1. Based on the treatments my loved one has previously taken, is he/she a candidate for LONSURF?
  2. How can LONSURF help?
  3. How and where is LONSURF taken?
  4. What dose of LONSURF would he or she take? How often?
  5. How often will we need to come into the office with this treatment?
  6. What happens if a dose is missed?
  7. What side effects could my loved one have?
  8. When should I call you if he or she is having signs and symptoms of side effects?
  9. How can I help my loved one manage any side effects?
  10. How will the treatment affect my loved one’s daily activities or ability to work?
  11. Does Taiho Oncology offer any financial assistance programs?
Download

Brochures

Treatment Companion

Treatment Companion
The Treatment Companion is a comprehensive brochure that can help you understand what LONSURF is, who it can help, and how it works. It also offers other helpful tips such as guidance related to financial assistance.

Patient Brochure
This booklet offers the information on this website in a downloadable format, including how LONSURF can help, how it is taken, tips on managing common side effects, and services that may be able to help with medication costs.

Caregiver Brochure
This brochure not only provides an overview of LONSURF and how it is taken, but it includes useful tips on how caregivers can help manage common side effects, as well as strategies for taking care of themselves and their loved ones.

Patient Assistance Brochure
This brochure features the information included in the Support Services section of this website in a downloadable format. It outlines the reimbursement and treatment services offered by Taiho Oncology Patient Support™, and how you can enroll in the program.

Potential Changes in your Treatment Brochure
This brochure examines the potential changes your HCP may make to your LONSURF treatment plan. The simple question and answer format addresses common concerns patients may have including why and how their treatment plan could change, and the likelihood of change occurring.


Videos

Patient Video:

The Importance of Taking your Medicine as Prescribed
Mollie Reed, Oncology Nurse, describes why taking your medication exactly as prescribed is so important, and goes over some general strategies to help you do just that.

Patient Video:

Tips for Taking your Medicine as Prescribed
In this video, Nurse Reed outlines six specific tips to help you stick to your treatment plan.

Caregiver Video:

Tips for Helping your Loved One Take Their Medicine as Prescribed
Watch Nurse Reed review steps that can help make it easier for your loved one to take LONSURF properly.

Important Safety Information +

LONSURF may cause serious side effects, including:

  • Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts

Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.

Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:

  • Have kidney problems
  • Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby
    • Females who can become pregnant should use effective birth control during treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
    • Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
  • Are breast‑feeding or plan to breast‑feed. It is not known if LONSURF passes into your breast milk. Do not breast‑feed during treatment with LONSURF and for 1 day after your last dose of LONSURF

Tell your healthcare provider about all the prescription and over‑the‑counter medicines, vitamins, and herbal supplements you take.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.