INDICATION: LONSURF® (trifluridine and tipiracil) tablets are a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
INDICATION: LONSURF® (trifluridine and tipiracil) tablets are a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
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Resources

LONSURF Starter Kit

LONSURF Patient Starter Kit

The LONSURF Starter Kit is meant to help you get the most out of your treatment. The materials provided are not meant to replace your healthcare provider's advice. Always speak with your healthcare provider about any questions or concerns you have. Together you and your healthcare provider can develop a personalized treatment plan based on your needs.

The LONSURF Starter Kit includes the following items:

  • LONSURF Treatment Companion
    Contains helpful information you and your caregiver should know about mCRC and LONSURF, including how to obtain treatment and financial support and ways to help manage common side effects while taking LONSURF
  • Treatment Calendar (pen included)
    Provides a place to record how you are feeling each day. You can take it to your appointments to help you remember what you want to discuss
  • LONSURF Offerings Flashcard
    Describes just a few of the helpful online resources available to you and your caregiver during your treatment journey with LONSURF
  • LONSURF Pillboxes
    Are designed to help you organize your medicine. One pillbox is for the first week of every treatment cycle (days 1 to 7), and the other is for the second week of every treatment cycle (days 8 to 14)
  • Carrying Case
    Can help you keep your LONSURF materials in 1 place—whether you're at home, at your appointments, or anywhere else
  • Thermometer
    To check your temperature regulary
LONSURF Patient Starter Kit

Doctor Discussion Guide

To receive a list of helpful questions to ask, please choose one of the following options. Remember to print or download your Guide and share it at your next appointment.

I am a patient

Talking to your healthcare provider about LONSURF® (trifluridine and tipiracil) tablets

If you have colon or rectal cancer that has spread to other parts of your body and have previously been treated with or cannot receive certain chemotherapy medicines, LONSURF might be another treatment option that can allow you to pursue more moments.

LONSURF was studied in a clinical trial of 800 patients.

  • Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
  • Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo

Your doctor or nurse can help you find out whether LONSURF is right for you. Be sure to bring this guide to your next appointment, and use the following questions to help start the conversation.

Look over the following options and check the treatment(s) you have already received:

  • Fluoropyrimidine ‑ such as 5‑fluorouracil, also known as 5-FU
  • Oxaliplatin‑based treatment ‑ such as FOLFOX (5‑FU, leucovorin, and oxaliplatin); CAPOX (capecitabine and oxaliplatin); or Eloxatin® (oxaliplatin)
  • Irinotecan‑based treatment ‑ such as FOLFIRI (5-FU, leucovorin, and irinotecan); CAPIRI (capecitabine and irinotecan); or Camptosar® (irinotecan)
  • Anti‑VEGF biological therapy, or VEGF inhibitors ‑ such as Avastin® (bevacizumab); or Zaltrap® (ziv‑aflibercept)
  • Anti‑EGFR therapy, or EGFR inhibitors (if you have the KRAS wild type gene) ‑ such as Erbitux® (cetuximab); or Vectibix® (panitumumab)

If you aren't sure what treatments you've had in the past, ask your healthcare provider.

Registered trademarks are the property of their respective owners.

In a clinical trial, LONSURF was shown to be effective in patients who had already taken some or all of the treatments mentioned above.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. However, for most patients in the trial, these side effects did not cause them to stop taking LONSURF (3.6% of patients taking LONSURF stopped vs 1.5% of patients taking placebo).

Additional questions to ask:

  1. Based on the treatments I have previously taken, could LONSURF be right for me?
  2. How can LONSURF help?
  3. How does LONSURF work?
  4. How and where do I take LONSURF?
  5. What is the dosage schedule?
  6. What would my dose be?
  7. How often will I need to come in to the office with this treatment?
  8. What happens if I miss a dose?
  9. When should I call you if I'm having signs and symptoms of side effects?
  10. How can I help manage any side effects I may have?
  11. How will my treatment affect my daily activities or my ability to work?
  12. Does Taiho Oncology offer any financial assistance programs?
Download

I am a caregiver

Talking to your loved one's healthcare provider about LONSURF® (trifluridine and tipiracil) tablets

For those with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines, LONSURF might be another treatment option that can allow them to pursue more moments.

LONSURF was studied in a clinical trial of 800 patients.

  • Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
  • Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo

Your loved one's doctor or nurse can help you find out whether LONSURF is right for your loved one. Be sure to bring this guide to your loved one's next appointment, and use the following questions to help start the conversation.

Look over the following options and check the treatment(s) your loved one has already received:

  • Fluoropyrimidine ‑ such as 5‑fluorouracil, also known as 5-FU
  • Oxaliplatin‑based treatment ‑ such as FOLFOX (5‑FU, leucovorin, and oxaliplatin); CAPOX (capecitabine and oxaliplatin); or Eloxatin® (oxaliplatin)
  • Irinotecan‑based treatment ‑ such as FOLFIRI (5-FU, leucovorin, and irinotecan); CAPIRI (capecitabine and irinotecan); or Camptosar® (irinotecan)
  • Anti‑VEGF biological therapy, or VEGF inhibitors ‑ such as Avastin® (bevacizumab); or Zaltrap® (ziv‑aflibercept)
  • Anti‑EGFR therapy, or EGFR inhibitors (if you have the KRAS wild type gene) ‑ such as Erbitux® (cetuximab); or Vectibix® (panitumumab)

Registered trademarks are the property of their respective owners.

In a clinical trial, LONSURF was shown to be effective in patients who had already taken some or all of the treatments mentioned above.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever. However, for most patients in the trial, these side effects did not cause them to stop taking LONSURF (3.6% of patients taking LONSURF stopped vs 1.5% of patients taking placebo).

Here are some questions to ask your loved one's healthcare provider at their next appointment:

  1. Based on the treatments my loved one has previously taken, is he/she a candidate for LONSURF?
  2. How can LONSURF help?
  3. How and where is LONSURF taken?
  4. What dose of LONSURF would he or she take? How often?
  5. How often will we need to come into the office with this treatment?
  6. What happens if a dose is missed?
  7. What side effects could my loved one have?
  8. When should I call you if he or she is having signs and symptoms of side effects?
  9. How can I help my loved one manage any side effects?
  10. How will the treatment affect my loved one’s daily activities or ability to work?
  11. Does Taiho Oncology offer any financial assistance programs?
Download

Brochures

Treatment Companion

Treatment Companion
Offers information on how LONSURF can help, how it is taken, tips on managing common side effects, and services that may be able to help with medication costs.

Caregiver Brochure
Provides an overview of LONSURF and how it is taken, useful tips that may help manage common side effects, and strategies for taking care of yourself and your loved one.


Video

Patient Video:

Tips for Taking your Medicine as Prescribed
In this video, Nurse Reed outlines six specific tips to help you stick to your treatment plan.

Important Safety Information +

LONSURF may cause serious side effects, including:

  • Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts

Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.

Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:

  • Have kidney or liver problems
  • Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby
    • Females who can become pregnant should use effective birth control during treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
    • Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
  • Are breast‑feeding or plan to breast‑feed. It is not known if LONSURF passes into your breast milk. Do not breast‑feed during treatment with LONSURF and for 1 day after your last dose of LONSURF

Tell your healthcare provider about all the prescription and over‑the‑counter medicines, vitamins, and herbal supplements you take.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.