INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
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Frequently asked questions about LONSURF® (trifluridine and tipiracil)

How does LONSURF work against colon or rectal cancer?

LONSURF is an oral chemotherapy that is 2 medicines in 1.

  • One part helps the other part stay active and work properly
  • The other part stops cells from making copies of themselves. This may help stop tumors from growing

What are the most common side effects associated with LONSURF?

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

Your healthcare provider should check your blood cell counts before you receive LONSURF, at day 15 during treatment, and as needed.

  • Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or low platelet counts
  • Tell a healthcare provider right away if you develop any signs of infection such as fever, chills, or body aches

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.

Please see full Prescribing Information.

How is LONSURF taken?

LONSURF is an oral tablet and comes in 2 strengths: 15‑mg and 20‑mg tablets.* Your healthcare provider may prescribe both strengths for your prescribed dose.

*Tablet strength of LONSURF is based on 1 active part of the medicine.

Doses are taken twice a day after breakfast and dinner (immediately after or up to 1 hour after).

  • LONSURF may cause a decrease in white blood cells. Taking LONSURF after morning and evening meals may help lessen this effect. This is important because a low white blood cell count can make you more prone to infection
  • The type of food does not matter

You will take LONSURF after morning and evening meals for 5 days a week, and then rest for 2 days. This goes on for 2 weeks. Then you will not take LONSURF for 2 weeks (14 days). This is repeated for as long as your healthcare provider says. Always follow your healthcare provider's directions carefully.

How should LONSURF be stored?

Store LONSURF at room temperature between 68° to 77°F (20° to 25°C).

Don't store LONSURF with other medicines. Keep LONSURF in its own container. If you store your tablets outside of the original container, any unused LONSURF tablets should be disposed of after 30 days.

If you have leftover tablets, speak with your healthcare provider or pharmacist about how to dispose of them properly.

NOTE: Anyone who handles LONSURF should wash his or her hands afterward. Make sure your caregiver wears gloves when handling LONSURF. Even though it is a pill, it is still chemotherapy.

What if my loved one or I have a question about LONSURF and the doctor's office is not available?

Contact our 24‑hour call center, where you can get answers to your questions about LONSURF, at 1‑844‑TAIHO‑4U1‑844‑TAIHO‑4U (1‑844‑824‑46481‑844‑824‑4648).

Does Taiho Oncology offer any financial assistance programs?

Yes. Taiho Oncology is committed to providing ongoing services that include treatment support, referral to financial assistance resources to help eligible patients pay for their medicine, informational e‑mails, and 24‑hour access to our call center, where you can get answers to your questions about LONSURF.

For more information about LONSURF financial support, call 1‑844‑TAIHO‑4U1‑844‑TAIHO‑4U (1‑844‑824‑46481‑844‑824‑4648) or go to TaihoPatientSupport.com.

Watch Mollie Reed, Oncology Nurse, explain why it is important to take LONSURF exactly as prescribed by your healthcare provider, and how to stay on track.
Important Safety Information +

LONSURF may cause serious side effects, including:

  • Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts

Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.

Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:

  • Have kidney problems
  • Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby
    • Females who can become pregnant should use effective birth control during treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
    • Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
  • Are breast‑feeding or plan to breast‑feed. It is not known if LONSURF passes into your breast milk. Do not breast‑feed during treatment with LONSURF and for 1 day after your last dose of LONSURF

Tell your healthcare provider about all the prescription and over‑the‑counter medicines, vitamins, and herbal supplements you take.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.