INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
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Already Taking LONSURF

About metastatic colon or rectal cancer (mCRC)

Fast facts about colon or rectal cancer:

  • It is the third most common cancer in men and women
  • Approximately 1 in 20 Americans will be diagnosed with colon or rectal cancer in his or her lifetime
  • In 2014, the number of people diagnosed with colon or rectal cancer in the United States was about:
    • 71,830 men
    • 65,000 women

What is refractory metastatic colon or rectal cancer?

Refractory means that the cancer may continue to grow despite treatment. The cancer may be resistant at the beginning of treatment or it may become resistant during treatment.

Metastatic means that the cancer has spread to other parts of the body.


Get the support you need

Meeting and learning from other people living with colon or rectal cancer can be helpful. Connect with others online or in a local support group.

You can find colon or rectal cancer information, support, and community at:

CancerCare®:
Go to cancercare.org or call 1‑800‑813‑HOPE (4673)1‑800‑813‑HOPE (4673)
Cancer Support Community (CSC):
Go to cancersupportcommunity.org or call 1‑888‑793‑93551‑888‑793‑9355
Fight Colorectal Cancer:
Go to fightCRC.org or call 1‑877‑427‑21111‑877‑427‑2111
Colon Cancer Alliance:
Go to ccalliance.org or call 1‑877‑422‑20301‑877‑422‑2030
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Important Safety Information +

LONSURF may cause serious side effects, including:

  • Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts

Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.

Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:

  • Have kidney problems
  • Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby
    • Females who can become pregnant should use effective birth control during treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
    • Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
  • Are breast‑feeding or plan to breast‑feed. It is not known if LONSURF passes into your breast milk. Do not breast‑feed during treatment with LONSURF and for 1 day after your last dose of LONSURF

Tell your healthcare provider about all the prescription and over‑the‑counter medicines, vitamins, and herbal supplements you take.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.