INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
INDICATION: LONSURF® (trifluridine and tipiracil) is a prescription medicine used to treat people with colon or rectal cancer that has spread to other parts of the body and who have previously been treated with or cannot receive certain chemotherapy medicines. It is not known if LONSURF is safe and effective in children.
Taking Care of Your Loved One
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What is LONSURF?

LONSURF® (trifluridine and tipiracil), a prescription medicine, is for people:

  • Whose colon or rectal cancer has spread to other parts of the body (this is called "metastatic")
  • Who have previously been treated with or cannot receive certain chemotherapy medicines
  • Who now may need another option

How LONSURF can help

Help your loved one understand that LONSURF has been proven to help some patients with refractory metastatic colon or rectal cancer (mCRC) live longer.

LONSURF was studied in a clinical trial of 800 patients.

  • Half of the patients treated with LONSURF were still alive at 7.1 months and half of the patients who received placebo were still alive at 5.3 months
  • Worsening of the disease or death occurred in 88% of patients treated with LONSURF and 94% of patients who received placebo

How it works

LONSURF, a prescription medicine, is an oral chemotherapy that is 2 medicines in 1.

  • One part helps the other part stay active and work properly
  • The other part stops cells from making copies of themselves. This may help stop tumors from growing

How LONSURF is taken

LONSURF is an oral tablet and comes in 2 strengths: 15‑mg and 20‑mg tablets.* The healthcare provider may prescribe both strengths for your loved one's prescribed dose.

*Tablet strength of LONSURF is based on 1 active part of the medicine.
 
LONSURF® (trifluridine and tipiracil) 15 mg and 20 mg tablets Tablets shown are not actual size.

Help make sure your loved one is taking LONSURF:

  • Twice a day
  • After breakfast and dinner (immediately after or up to 1 hour after)
    • LONSURF may cause a decrease in white blood cells. Taking LONSURF after morning and evening meals may help lessen this effect. This is important because a low white blood cell count can make your loved one more prone to infection
    • The type of food does not matter

LONSURF 28‑day treatment schedule

LONSURF® (trifluridine and tipiracil) tablets Treatment Schedule

The dosage schedule is 5 days a week with 2 days rest for 2 weeks, then no treatment for 2 weeks (14 days). The doctor may repeat this cycle. Always follow the healthcare provider's directions carefully.

See more dosage directions

Other things to keep in mind about taking LONSURF:

  • Store LONSURF at room temperature between 68°F and 77°F (20°C to 25°C)
  • Don't store LONSURF with other medications. Keep LONSURF in its own container
  • If tablets are stored outside of the original container, any unused LONSURF tablets should be disposed of after 30 days
  • Anyone who handles LONSURF should wash his or her hands afterward. Even though it is a pill, it is still chemotherapy
  • You should wear gloves when handling LONSURF
  • Note that there is a packet inside the bottle that helps absorb moisture. This material should not be swallowed
  • Keep LONSURF out of the reach of children

Contact your loved one's healthcare provider:

  • If your loved one misses a dose of LONSURF, he or she should not take the missed dose. Instead, check with a healthcare provider about how to proceed
  • If for some reason your loved one has leftover tablets, you should speak with a healthcare provider or pharmacist about how to dispose of them properly

Video

Tips for helping your loved one

Tips for helping your loved one take their medicine as prescribed

Watch Mollie Reed, Oncology Nurse, review steps that can help make it easier for your loved one to take LONSURF properly.

Create and print a personalized Treatment Calendar.

Side effects

A healthcare provider should check your loved one's blood cell counts before he or she receives LONSURF, at day 15 during treatment, and as needed.

  • Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in white blood cells, red blood cells, and platelets. Low white blood cells can make your loved one more likely to get serious infections that could lead to death. A healthcare provider may lower the dose of LONSURF or stop LONSURF if your loved one has low white blood cells or low platelet counts
  • Tell a healthcare provider right away if your loved one develops any signs of infection such as fever, chills, or body aches

Fever is often the first sign of infection in people with cancer. Remember to check your loved one's temperature each day.

Keep an eye out for other signs of infection, like:

  • Chills or sweats
  • Sore throat
  • Cough or shortness of breath
  • Burning or pain when urinating

General infection tips

  • Wash hands frequently
  • Maintain a balanced diet
  • Stay hydrated
  • Clean cuts and scrapes in the skin
  • Clean the anus with moist towelettes or baby wipes after bowel movements
  • Get plenty of sleep

The most common side effects

Almost all patients treated with LONSURF experience side effects at some time. Some patients in a clinical trial had one or more of these:

  • Tiredness
  • Nausea
  • Vomiting
  • Decreased appetite
  • Diarrhea
  • Abdominal pain
  • Fever

Talk to your loved one's healthcare provider if he or she has nausea, vomiting, or diarrhea that is severe or that does not go away. These are not all of the possible side effects of LONSURF.

You can track any side effects or other issues on their personalized Dosage Calendar. Bring the calendar with you to his or her doctors' appointments as a reminder of what to discuss with your loved one's healthcare providers.

You can also call the Taiho Oncology 24/7 hotline with questions about side effects with LONSURF at 1‑844‑US‑TAIHO1‑844‑US‑TAIHO (1‑844‑878‑24461‑844‑878‑2446). You may report side effects to the FDA at 1‑800‑FDA‑10881‑800‑FDA‑1088.

Managing side effects: Some tips to try

Your loved one's healthcare provider may have ways to help manage some of the side effects of LONSURF. This could include adjusting your loved one's treatment plan by changing the dosage or stopping treatment.

The following information may also be helpful to you or your loved one in managing some of the side effects of LONSURF while under a healthcare provider's care; however, these tips may not always work.

This information is not meant to replace the advice of your loved one's healthcare provider. Always discuss any side effects with a healthcare provider.

Choose one or more to get helpful ideas:

Tiredness

Some tips for managing tiredness

Help your loved one:

  • Set reasonable goals each day and don't let them overdo it
  • Prioritize important tasks over less important ones
  • Plan time to rest or nap (less than 1 hour). Keeping naps short will help with better sleep at night
  • Stay active. Talk with your healthcare provider about exercise that can help, like going for a 15‑minute walk, doing yoga, or riding an exercise bike
  • Get at least 8 hours of sleep each night
  • Establish a bedtime routine. Bathing or listening to relaxing music before bed may help

Nausea and vomiting

Some tips for managing nausea and vomiting

Remind your loved one to:

  • Make 5 or 6 small meals a day, instead of 3 big ones (this does not change the dosage schedule)
  • Have food and drinks that are warm or cool instead of hot or cold
  • Choose foods that are easy on the stomach, like saltine crackers or angel food cake
  • Avoid certain foods. Don't eat greasy, fried, sweet, or spicy foods if you feel sick after eating them
  • Take any medicine a healthcare provider prescribes to help with nausea

Decreased appetite

Some tips for managing decreased appetite

Remind your loved one to:

  • Make 5 or 6 small meals a day, instead of 3 big ones (this does not change the dosage schedule)
  • Have milkshakes, smoothies, juice, or soup instead of solid food
  • Choose foods that are high in calories and/or protein
  • Stay active. Talk with a healthcare provider about exercises that can help, like going for a 15‑minute walk
  • Plan some meals with friends and loved ones
  • Ask a healthcare provider about seasonings that may help some foods taste better
  • Take note of how much he or she is eating and drinking each day

Diarrhea/abdominal pain

Some tips for managing diarrhea/abdominal pain

For diarrhea, encourage your loved one to:

  • Make 5 or 6 small meals a day, instead of 3 big ones (this does not change the dosage schedule)
  • Eat low‑fiber foods. Foods that are high in fiber can make diarrhea worse. Low‑fiber foods include bananas, white rice, white toast, and plain or vanilla yogurt
  • Have food and drinks that are warm or cool instead of hot or cold
  • Eat bland foods instead of greasy, fried, salty, sweet, or spicy foods
  • Avoid dairy products, such as milk, cheese, and sour cream
  • Avoid alcohol and caffeine
  • Drink plenty of liquids to replace the fluids being lost
  • Use warm water and a towelette if the rectal area becomes sore, and keep the area dry. Also, to ask a healthcare provider about creams that can help
  • Take any medicine that a healthcare provider prescribes to help with diarrhea

For abdominal pain, remind your loved one to:

  • Eat plenty of foods that are high in fiber such as fruits and vegetables
  • Avoid foods that produce gas
  • Exercise regularly

Fever

Some tips for managing fever

Remind your loved one to:

  • Drink plenty of liquids, like water, juice, and broth
  • Get rest
  • Keep cool with light clothing and by sleeping with only a sheet
  • Call a healthcare provider immediately if he or she has a fever or other signs of infection such as chills or body aches. Remember to check your loved one's temperature each day

Tell your loved one's healthcare provider if he or she has nausea, vomiting, or diarrhea that is severe or that does not go away.

You can call the Taiho Oncology 24/7 hotline with questions about side effects with LONSURF at 1‑844‑US‑TAIHO1‑844‑US‑TAIHO (1‑844‑878‑24461‑844‑878‑2446). You may report side effects to the FDA at 1‑800‑FDA‑10881‑800‑FDA‑1088.

Download the full Caregiver brochure:

Find out about services that may help with medication costs
Important Safety Information +

LONSURF may cause serious side effects, including:

  • Low blood counts. Low blood counts are common with LONSURF and can sometimes be severe and life‑threatening. LONSURF can cause a decrease in your white blood cells, red blood cells, and platelets. Low white blood cells can make you more likely to get serious infections that could lead to death. Your healthcare provider should do blood tests before you receive LONSURF, at day 15 during treatment with LONSURF, and as needed to check your blood cell counts. Your healthcare provider may lower your dose of LONSURF or stop LONSURF if you have low white blood cell or platelet counts

Tell your healthcare provider right away if you get any of the following signs and symptoms of infection during treatment with LONSURF: fever, chills, or body aches.

Before taking LONSURF, tell your healthcare provider about all of your medical conditions, including if you:

  • Have kidney problems
  • Are pregnant or plan to become pregnant. LONSURF can harm your unborn baby
    • Females who can become pregnant should use effective birth control during treatment with LONSURF. Tell your healthcare provider immediately if you become pregnant
    • Males, while on treatment and for 3 months after your last dose of LONSURF, you should use a condom during sex with female partners who are able to become pregnant. Tell your healthcare provider right away if your partner becomes pregnant while you are taking LONSURF
  • Are breast‑feeding or plan to breast‑feed. It is not known if LONSURF passes into your breast milk. Do not breast‑feed during treatment with LONSURF and for 1 day after your last dose of LONSURF

Tell your healthcare provider about all the prescription and over‑the‑counter medicines, vitamins, and herbal supplements you take.

The most common side effects with LONSURF include tiredness, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and fever.

Tell your doctor if you have nausea, vomiting, or diarrhea that is severe or that does not go away.

These are not all of the possible side effects of LONSURF. For more information, ask your healthcare provider. Call your doctor for medical advice about side effects.